Long noncoding RNA in cardiac aging and disease

Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease

Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL) , which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes.  These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of...

Long Noncoding RNA Discovery in Cardiovascular Disease

Despite substantial progress in understanding disease mechanisms and the approval of multiple new therapies, for the first time in 3 decades, we are witnessing an increase in overall cardiovascular deaths. Recently, the discovery of an attractive group of molecules known as long noncoding RNAs (lncRNAs) has introduced a new catalog of diagnostic and therapeutic opportunities for cardiovascular ...

Study of Long Noncoding RNA FER1L4 and RB1, as Its Competing Endogenous RNA Network Target Gene, in Breast Cancer

Introduction: Breast cancer is the second most common cause of cancer-related death among females, which requires an exploration for markers to propose a more specific categorization of this cancer. Long noncoding RNAs (lncRNAs), the main subset of noncoding transcripts, are involved in tumorigenic processes. In this study, we investigated the expression of the fer-­1–­like family member 4 (FER...

Long Noncoding RNAs in Aging

Aging is associated with increasing the risk of disease and death. Recently, increasing evidences suggest that many long noncoding RNAs (lncRNAs) function through specific interactions with other cellular factors, namely proteins, DNA, and other RNA molecules. LncRNAs play important roles in a wide range of age-related diseases, such as cancer, cardiovascular pathologies, and neurodegenerative ...

Long Noncoding RNA-GAS5